Expanding Chemical Space Beyond Two Dimensions
To expand the number of druggable proteins, chemists are relying on metathesis to build scaffolds that were previously inaccessible via traditional chemistry. These scaffolds are expanding novel classes of lead compounds capable of engaging new, high value drug targets.
Macrocyclic Compounds: Oral Bioavailability Beyond Rule-of-5 Space
As medicinal chemists venture into uncharted chemical territory in pursuit of molecules capable of modulating new targets, physical and pharmacokinetic properties like solubility, cell permeability, and metabolic stability become more difficult to predict and control.